Table 2.
Hazard ratiosa per SD of breast density assessments and breast cancer risk, by view and machine type
| LIBRA (MLOb only) | LIBRA (CCb only) | Cumulus | |
|---|---|---|---|
| Hologic DA | 1.44 (1.33–1.56) | 1.28 (1.19–1.38) | 1.47 (1.36–1.58) |
| GE DA | 1.24 (1.06–1.46) | 1.22 (1.04–1.43) | 1.33 (1.11–1.58) |
| Combinedc DA | 1.36 (1.18–1.57) | 1.27 (1.18–1.36) | 1.44 (1.33–1.55) |
| Hologic NDA | 0.85 (0.76–0.94) | 0.87 (0.78–0.96) | 0.80 (0.72–0.89) |
| GE NDA | 0.85 (0.68–1.07) | 0.92 (0.74–1.14) | 0.87 (0.70–1.09) |
| Combinedc NDA | 0.85 (0.77–0.93) | 0.88 (0.80–0.96) | 0.81 (0.74–0.89) |
| Hologic PD | 1.52 (1.39–1.67) | 1.35 (1.23–1.48) | 1.61 (1.47–1.77) |
| GE PD | 1.31 (1.08–1.58) | 1.25 (1.04–1.50) | 1.39 (1.13–1.70) |
| Combinedc PD | 1.44 (1.26–1.66) | 1.33 (1.22–1.44) | 1.54 (1.34–1.77) |
LIBRA and Cumulus DA and PD were log-transformed, and LIBRA and Cumulus NDA were untransformed
aHazard ratios adjusted for age at FFDM (spline), mammogram year (categorical), BMI (spline), parity, first-degree family history, and HRT use within 5 years prior to mammogram date. Cumulus analyses were also adjusted for image batch. HRs are per standard deviation of density based on distribution in full cohort
bAverage of measures on right and left breasts
cMeta-analysis was used to combine Hologic and GE results