Fig. 2.

Cox proportional regression fracture-free survival in early RA patients according to risk factors. Illustrates Cox regression curves adjusted for age, sex, period of inclusion, BMI, smoking, prior fracture, osteoporosis, hypertension, DAS28 at baseline or a cumulative DAS over first 2 years after inclusion. HR, hazard ratio; sustained = if values were reached and maintained at follow-up at 6-month, 1- and 2-year; DAS28-remission = DAS28 ≤ 2.6; DAS28-LDA = DAS28 low disease activity if DAS28 ≤ 3.2; RF, rheumatoid factor; ACPA, RF, rheumatoid factor; ACPA, anti-citrullinated protein antibodies; low HAQ = HAQ ≤ 0.5; erosion score progression = if a change ≥ 1 unit at 2-year in comparison with baseline