TABLE 4.
Concentrations of Fab fragment RSV19 and purified human polyclonal IgG preparations required to achieve 50% virus neutralization in vitro and 50% maximum binding to the RSV-infected cell surface
| Preparationa | Concn (μg/ml) required for 50%
|
|
|---|---|---|
| Maximum bindingb | Plaque reductionc | |
| RSV19 | 0.58 | 0.23 |
| IgGp1 | 64 | 11 |
| IgGp2 | 87 | 32 |
a
IgGp1 is a polyclonal IgG preparation from pooled human sera from two normal donors. IgGp2 is a polyclonal IgG preparation from an HIV-1-seropositive donor.
b
Measured by flow cytometry.
c
Measured as neutralization activity without complement by a plaque assay.