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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Pharmacol Biochem Behav. 2022 Aug 18;219:173450. doi: 10.1016/j.pbb.2022.173450

Figure 1. Synaptic locus dissociation of mGlu2 and mGlu3 receptor functions in mouse prefrontal cortex.

Figure 1.

Presynaptic mGlu2 receptors gate glutamate release probability in PFC. At synapses arising from the MDT, presynaptic mGlu2 receptors can induce a long-term depression (LTD) of excitatory transmission. By contrast, neuronal mGlu3 receptors mediate a postsynaptic form of LTD. Postsynaptic mGlu3 LTD proceeds through the coordinated signaling of mGlu5 receptors, phosphoinositide 3-kinase (PI3K), Akt, glycogen synthase kinase-3 (GSK-3), and the internalization of AMPA receptors. mGlu3 LTD is also differentially expressed across long-range inputs to PFC, having been observed at synapses arising from the MDT and BLA, but not the ventral hippocampus.