Table 1.
Effects of mGlu2 and mGlu3 receptors across brain circuits involved in mood disorders and alcohol use disorder
| Brain Region | Synaptic Plasticity |
|---|---|
| Prelimbic Prefrontal Cortex | ▪ mGlu2/3 agonism attenuates glutamate release and promotes LTD (31-43) ▪ mGlu2 regulates glutamate release (33-35,43) ▪ mGlu3 mediates postsynaptic LTD via AMPAR internalization (38-43) |
| Hippocampus | ▪ mGlu2/2 homodimers regulate glutamate release at mossy fiber (20) ▪ mGlu2/4 heterodimers regulate glutamate release in perforant path (46) ▪ mGlu3 activation promotes NMDAR-LTP (50, 51) ▪ Glial mGlu3 regulates adrenergic plasticity (54, 55) |
| Striatum | ▪ mGlu2 regulates glutamate and dopamine release (44, 58) ▪ mGlu2/3 agonism induces LTD in the nucleus accumbens (61) |
| Amygdala | ▪ mGlu2/3 agonism attenuates glutamate release and induces LTD in BLA (62), LA (63), CEA (64), and BNST (65) |
Abbreviations: BLA, basolateral amygdala; BNST, bed nucleus of the stria terminalis; CEA, central nucleus of the amygdala; LA, lateral amygdala; LTD, long-term depression; LTP, long-term potentiation