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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Pharmacol Biochem Behav. 2022 Aug 18;219:173450. doi: 10.1016/j.pbb.2022.173450

Table 2.

Physiochemical and behavioral properties of novel mGlu2 and mGlu3 negative allosteric modulators

Compound Target IC50 (μM) Brain Kp T1/2 (min) Dose i.p. (mg/kg) Behavioral Effects Refence
VU6001966 mGlu2 78 1.9 20 10 – 30 ↔ immobility TST
↓ immobility FST		 Bollinger et al. J Med Chem Letters. 2017
VU0650786 mGlu3 392 1.7 49 10 – 56.5 ↓ marble burying
↓ immobility TST and FST reverse anhedonia and amotivation after stressors		 Engers et al. J Med Chem. 2015
VU6010572 mGlu3 245 1.15 ? 1.8 – 3 (mouse/rat) ↓ immobility TST
↑ open arm time EPM (rat)
↓ habituation to startle (rat)
↓ TMT-induced hyperactivity (rat)		 Engers et al. J Med Chem Letters. 2017

Note: Findings are from mouse studies unless otherwise specified

Abbreviations: EPM, elevated pus maze; FST, forced swim test; TMT, trimethylthiazoline predator odor; TST, tail suspension test