Table 2a.
Treatment effect on outcomes in the EAST-AFNET 4 trial ‘PRS’-sub-population adjusted for genetic AF risk
| Outcome | Early rhythm control | Usual care | Treatment effecta |
P-value |
|---|---|---|---|---|
| Primary outcome—events/person-year (incidence/100 person-years) | 125/3810.0 (3.3) | 171/3729.0 (4.6) | 0.67 (0.53, 0.84) | <0.001 |
| Components of primary outcome—events/person-year (incidence/100 person-years) | ||||
| Death from cardiovascular causes | 35/4002.0 (0.9) | 54/3845.0 (1.4) | 0.62 (0.40, 0.95) | 0.029 |
| Stroke | 18/3955.0 (0.5) | 33/3769.0 (0.9) | 0.52 (0.29, 0.94) | 0.03 |
| Hospitalization with worsening of HF | 74/3851.0 (1.9) | 90/3618.0 (2.5) | 0.77 (0.56, 1.04) | 0.094 |
| Hospitalization with acute coronary syndrome | 21/3941.0 (0.5) | 38/3750.0 (1.0) | 0.52 (0.30, 0.89) | 0.019 |
| Secondary outcome— events/person-year (incidence/100 person-years) | ||||
| Recurrent atrial fibrillation | 322/2620.0 (12.3) | 391/2204.0 (17.7) | 0.76 (0.65, 0.88) | <0.001 |
Number of events per person years (incidence per 100 person-years) given.
expressed as HR from Cox regression model adjusted for continuous genetic AF risk and centre as shared frailty term.