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Association of PRS-AF as a continuous variable with cardiovascular outcomes in the EAST-AFNET 4 trial
| Genetic AF risk | ||
|---|---|---|
| Outcome | Hazard ratio (95% CI) | P-value |
| EAST-AFNET 4 primary outcome | 0.99 (0.88–1.11) | 0.867 |
| Components primary outcome | ||
| Death from cardiovascular causes | 0.99 (0.80–1.23) | 0.962 |
| Stroke | 1.10 (0.83–1.45) | 0.506 |
| Worsening of HF | 1.00 (0.86–1.17) | 0.974 |
| Acute coronary syndrome | 0.91 (0.70–1.19) | 0.492 |
| Secondary outcome | ||
| Recurrent atrial fibrillation | 1.08 (1.0–1.16) | 0.047 |
