Table 3.
Association of PRS-stroke with incident disease in the UK biobank using adjusted cox regression models. Hazard ratio as 1 SD change of the PRS on the risk of incident disease
| Disease | N overall cohort | N incident disease | Hazard ratio (95% CI) | P-value |
|---|---|---|---|---|
| HF | 406 710 | 12 388 | 1.08 (1.06–1.10) | <0.001 |
| HF (excluding AF) | 401 999 | 8713 | 1.03 (1.01–1.05) | 0.001 |
| Atrial fibrillation/atrial flutter (AF) | 403 192 | 24 767 | 1.15 (1.14–1.67) | <0.001 |
| Stroke | 402 532 | 4468 | 1.08 (1.06–1.11) | <0.001 |
| Ischemic stroke | 407 311 | 3490 | 1.11 (1.08–1.14) | <0.001 |
AF, atrial fibrillation.