Table 4b.

Safety events by genetic stroke risk category and treatment group

	Genetic stroke risk
	Low genetic stroke risk		Intermediate genetic stroke risk		High genetic stroke risk
	Early rhythm control	Usual Care	Early rhythm control	Usual care	Early rhythm control	Usual care
n	164	150	480	459	149	165
EAST primary composite safety outcome	17 (10.37)	25 (16.67)	80 (16.67)	69 (15.03)	26 (17.45)	30 (18.18)
Stroke	5 (3.05)	5 (3.33)	9 (1.88)	23 (5.01)	4 (2.68)	5 (3.03)
Death	6 (3.66)	7 (4.67)	24 (5.0)	35 (7.63)	5 (3.36)	12 (7.27)
Serious adverse event related to anti-arrhythmic drug therapy
Non-fatal cardiac arrest	0 (0)	0 (0)	0 (0)	0 (0)	1 (0.67)	1 (0.61)
Drug-induced bradycardia	2 (1.22)	1 (0.67)	7 (1.46)	2 (0.44)	1 (0.67)	1 (0.61)
Torsade de Pointes tachycardia	0 (0)	0 (0)	1 (0.21)	0 (0)	0 (0)	0 (0)
Drug toxicity of AF-related drug therapy	1 (0.61)	1 (0.67)	1 (0.21)	1 (0.22)	5 (3.36)	1 (0.61)
Artrioventricular block	0 (0)	0 (0)	2 (0.42)	0 (0)	0 (0)	0 (0)
Serious adverse event related to AF ablation
Major bleeding related to AF ablation	0 (0)	0 (0)	1 (0.21)	0 (0)	0 (0)	0 (0)
Nonmajor bleeding related to AF ablation	0 (0)	1 (0.67)	0 (0)	0 (0)	0 (0)	0 (0)
Other serious adverse event of special interest related to rhythm-control therapy
Other event	0 (0)	0 (0)	1 (0.21)	0 (0)	0 (0)	1 (0.61)
Other cardiovascular event	0 (0)	0 (0)	3 (0.62)	0 (0)	0 (0)	0 (0)
Hospitalization for AF	0 (0)	1 (0.67)	6 (1.25)	0 (0)	2 (1.34)	0 (0)
Syncope	1 (0.61)	1 (0.67)	1 (0.21)	0 (0)	1 (0.67)	0 (0)
Hospitalization for worsening of HF with decompensated HF	0 (0)	0 (0)	2 (0.42)	0 (0)	0 (0)	0 (0)
Implantation of a pacemaker, ICD, CRT or any other	1 (0.61)	1 (0.67)	4 (0.83)	1 (0.22)	0 (0)	0 (0)

AF, atrial fibrillation; HF, heart failure; ICD, implantable cardiac device; CRT, cardiac resynchronization therapy.