Table 2.
Baseline characteristics of cohort participants with follow-up spirometry
| Population-based |
Smoking-enriched LSC |
COPD-enriched COPDGene |
||
|---|---|---|---|---|
| FHS | KORA | |||
| N | 1,326 | 495 | 217 (100) | 739 |
| Interval between first and last spirometry, yr, mean (SD) | 6.9 (1.1) | 6.5 (0.5) | 1.2 (0.3) | 5.4 (0.7) |
| Age, yr, mean (SD) | 54 (10) | 53.7 (4.4) | 55.6 (8.7) | 61.6 (8.9) |
| Male | 605 (45.6) | 229 (46.3) | 46 (21.2) | 340 (46.0) |
| Body mass index, kg/m2, mean (SD) | 27.4 (5.0) | 27.4 (4.6) | 27.3 (5.5) | 28.9 (5.9) |
| Race, White-European/Non-Hispanic | 1,556 (100) | 495 (100) | 144 (66.4) | 662 (89.6%) |
| Race, Black-African | 0 (0) | 0 (0) | 1 (0.5) | 77 (10.4%) |
| Race, Hispanic | 0 (0) | 0 (0) | 64 (29.5) | 0 (0) |
| Current smoker | 241 (18.2) | 80 (16.2) | 132 (60.8) | 255 (34.5) |
| Never-smoker | 490 (37) | 193 (39.0) | NA | 27 (3.7) |
| Smoking pack-year history, mean (SD) | 15.7 (20.1) | 21.0 (19.9) | 41.5 (19.6) | 41.4 (25.2) |
| FEV1, L, prebronchodilator, mean (SD) | 2.90 (0.77) | 3.3 (0.8) | 2.54 (0.8) | 2.3 (0.9) |
| FEV1 % predicted, prebronchodilator, mean (SD) | 93 (15) | 103.1 (15.4) | 88.1 (19) | 78.1 (24.2) |
| FVC % predicted, prebronchodilator, mean (SD) | 98 (13) | 103.2 (12.9) | 93.5 (14.9) | 88.3 (17.5) |
| FEV1 decline, ml/yr, mean (SD) | 30.3 (25.2) | 56.3 (40.8) | 64.7 (37.1) | 37.6 (55.3) |
| PRISm | 82 (6) | 18 (3.6) | 17 (7.8) | 69 (9.3) |
| GOLD 1 | 170 (13) | 27 (5.5) | 13 (6) | 68 (9.2) |
| GOLD 2 | 136 (10) | 16 (3.2) | 31 (14.3) | 135 (18.3) |
| GOLD 3 | 13 (1) | 1 (0.2) | 8 (3.7) | 71 (9.6) |
| GOLD 4 | 0 (0) | 0 (0) | 3 (1.4) | 20 (2.7) |
Definition of abbreviations: COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume in 1 second; FHS = Framingham Heart Study; FVC = forced vital capacity; GOLD = Global Initiative for Chronic Obstructive Lung Disease; KORA = Kooperative Gesundheitsforschung in der Region Augsburg (Southern Germany); LSC = Lovelace Smokers Cohort; MESA = Multi-Ethnic Study of Atherosclerosis; PRISm = preserved ratio impaired spirometry; SD = standard deviation; SPIROMICS = Subpopulations and Intermediate Outcome Measures in COPD Study.
Entries represent n (%) unless otherwise noted. PRISm defined as FEV1/FVC ⩾ 0.7 and FEV1 % predicted according to Hankinson equations < 80%.