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. Author manuscript; available in PMC: 2023 Aug 7.
Published in final edited form as: Birth Defects Res. 2023 Apr 26;115(10):980–997. doi: 10.1002/bdr2.2176

TABLE 7.

Percentage of live births surviving at various timepoints from day 1 to 5 years including overall survival. Data are presented for total CLP for all 22 reporting ICBDSR programs and data for subclassifications where available.

Percentage surviving
Sub-classification Region Center Live births Count Day
<1
Days
1–6
Days 7–27 28 Days–11 Months Years 1–4 5 years + Overall
survival
Total Spain ECEMC hospitals reporting ETOPFA 101 99 99 99 99 99 99 99
Iran 156 98.7 98.1 98.1 98.1 98.1 98.1 98.1
Germany Saxony-Anhalt 443 99.1 98 97.1 96.2 96.2 96.2 96.2
Italy Lombardy 52 100 100 100 96.2 96.2 96.2 96.2
UK Wales 336 99.4 97 96.1 95.8 95.8 95.5 95.5
Italy Tuscany 184 98.4 96.7 96.7 95.1 95.1 95.1 95.1
Slovak 447 100 95.3 Not Not recorded Not Not 94.6
Republic recorded recorded recorded
France Paris 308 96.8 95.8 94.5 Not recorded Not Not 94.2
recorded recorded
Spain ECEMC hospitals not reporting ETOPFA 557 95.5 93.7 93.7 93.7 93.7 93.7 93.7
Czech 1,096 99.4 97.9 97.4 94.5 93.8 93.2 93.2
Republic
Netherlands EUROCAT Northern Netherlands 466 98.7 97.4 95.7 93.8 92.9 92.7 92.7
Ukraine OMNI-Net BD Program 191 99.5 96.3 94.2 92.7 91.6 91.6 91.6
Mexico RYVEMCE 1,124 94 91.4 91.4 91.4 91.4 91.4 91.1
Sweden 2,972 98.4 96.4 95.2 92.8 92.1 90.9 90.9
Colombia Cali 11 100 100 100 90.9 90.9 90.9 90.9
USA Arkansas 498 97.4 94.6 92.6 90 89.2 89 89
USA Atlanta 392 96.7 92.9 89.8 87.8 87.5 87.2 87.2
USA Utah 699 95 91.6 90.1 87.6 86.7 86.4 86.4
Argentina RENAC 955 100 86.3 86.3 86.3 86.3 86.3 86.3
Malta 34 100 94.1 91.2 85.3 85.3 85.3 85.3
S-America ECLAMC 2,594 90.4 86 83.2 82.8 82.8 82.8 82
Mexico Nuevo Léon 44 97.7 93.2 86.4 81.8 81.8 81.8 81.8
Israel 54 100 94.4 92.6 83.3 83.3 81.5 81.5
Total averages 98 95 93.8 91.5 91.3 91.1 91
Isolated Spain_ ECEMC reporting ETOPFA 77 100 100 100 100 100 100 100
Italy Lombardy 37 100 100 100 100 100 100 100
Malta 20 100 100 100 100 100 100 100
Germany Saxony-Anhalt 371 100 99.7 99.7 99.7 99.7 99.7 99.7
France Paris 254 99.6 99.6 99.6 Not recorded Not
recorded
Not
recorded
99.6
UK Wales 253 100 99.6 99.6 99.6 99.6 99.6 99.6
Spain_ ECEMC hospitals not reporting ETOPFA 388 99.5 99.5 99.5 99.5 99.5 99.5 99.5
Slovak
Republic
348 100 99.1 Not
recorded
Not recorded Not
recorded
Not
recorded
99.1
Ukraine OMNI-Net BD Program 156 100 100 99.4 98.7 98.7 98.7 98.7
Netherlands EUROCAT Northern Netherlands 391 99.7 99.2 99 98.7 98.5 98.5 98.5
Sweden 2,437 99.8 99.5 99.3 98.7 98.6 97.6 97.6
USA Utah 511 99.6 98.6 98.6 97.7 97.5 97.5 97.5
Mexico RYVEMCE 878 98.1 97.4 97.4 97.4 97.4 97.4 97.2
Argentina RENAC 696 100 97.1 97.1 97.1 97.1 97.1 97.1
S-America ECLAMC 1,673 98.7 97.8 97 97 97 97 96.9
Colombia Cali 11 100 100 100 90.9 90.9 90.9 90.9
Israel 45 100 93.3 91.1 88.9 88.9 88.9 88.9
Isolated averages 99.7 98.9 98.6 97.8 97.8 97.7 97.7
Multiple Congenital Anomalies Spain ECEMC hospitals reporting ETOPFA 20 100 100 100 100 100 100 100
UK Wales 55 100 90.9 90.9 89.1 89.1 89.1 89.1
Germany Saxony-Anhalt 56 96.4 94.6 91.1 87.5 87.5 87.5 87.5
Italy Lombardy 15 100 100 100 86.7 86.7 86.7 86.7
Spain ECEMC not reporting ETOPFA 110 89.1 84.5 84.5 84.5 84.5 84.5 84.5
Slovak
Republic
90 100 85.6 Not
recorded
Not recorded Not
recorded
Not
recorded
84.4
France Paris 37 89.2 86.5 86.5 Not recorded Not
recorded
Not
recorded
83.8
Malta 11 100 90.9 81.8 81.8 81.8 81.8 81.8
Netherlands EUROCAT Northern Netherlands 35 94.3 94.3 85.7 80 80 80 80
Ukraine OMNI-Net BD Program 24 100 83.3 79.2 79.2 79.2 79.2 79.2
USA Utah 116 89.7 85.3 82.8 77.6 75 75 75
Mexico RYVEMCE 141 81.6 72.3 72.3 72.3 72.3 72.3 71.6
Sweden 331 94 89.1 84 76.4 73.7 71.6 71.6
Argentina RENAC 232 100 59.1 59.1 59.1 59.1 59.1 59.1
S-America ECLAMC 921 75.5 64.6 58.1 57.1 57.1 57.1 54.8
Israel 9 100 100 100 55.6 55.6 44.4 44.4
MCA averages 94.35 86.32 83.84 78.68 78.35 77.52 77.1
Genetic / Chromosomal Spain ECEMC hospitals reporting ETOPFA 4 75 75 75 75 75 75 75
UK Wales 28 92.86 85.71 75 75 75 75 75
Spain_ ECEMC hospitals not reporting ETOPFA 59 81.36 72.88 72.88 72.88 72.88 72.88 72.88
Mexico RYVEMCE 105 76.19 66.67 66.67 66.67 66.67 66.67 66.67
Netherlands EUROCAT Northern Netherlands 40 92.5 82.5 72.5 57.5 50 47.5 47.5
Slovak
Republic
13 100 61.54 Not
recorded
Not recorded Not
recorded
Not
recorded
46.15
Germany Saxony-Anhalt 16 87.5 68.75 56.25 43.75 43.75 43.75 43.75
Sweden 204 89.22 71.57 65.2 49.02 44.61 42.16 42.16
Argentina RENAC 27 100 40.74 40.74 40.74 40.74 40.74 40.74
France Paris 17 70.59 58.82 35.29 Not recorded Not
recorded
Not
recorded
35.29
USA Utah 72 70.83 51.39 41.67 31.94 29.17 26.39 26.39
Czech
Republic
33 93.94 72.73 66.67 39.39 33.33 24.24 24.24
Ukraine OMNI-Net BD Program 11 90.91 72.73 54.55 36.36 18.18 18.18 18.18
Italy Lombardy 1 100 100 100 0 0 0 0
Malta 3 100 66.67 66.67 0 0 0 0
Genetic/chromosomal averages 88.1 69.8 63.4 45.7 43.1 42 40.9

Note: Not all registries reported all deaths at all timepoints, data in this table reports deaths where data was returned. Where data were confirmed as not reported by a registry this have been presented in the table and the overall survival covers only the time period for which data were returned.

Abbreviations: CLP, Cleft lip with palate; ECEMC, Registry of the Spanish Collaborative Study of Congenital Malformations; ECLAMC, Latin American Collaborative Study of Congenital Malformations; ETOPFA, early termination of pregnancy for fetal anomaly; ICBDSR, International Clearing House for Birth defects Surveillance and Research; MCA, Multiple Congenital Anomalies; RENAC, National Network of Congenital Anomalies of Argentina; RYVEMCE, Mexican Registry and Epidemiological Surveillance of External Congenital Malformations; SMC, Soroka Medical Center; UK, United Kingdom; USA, United States of America.