FIGURE 4.

Saline and TCEP lavage improve nasal airspace in a murine model of PCD compared to sham treatment. Groups of PCD mice were treated three times by nasal lavage, and the change in nasal airspace was measured. (A) At baseline, mice in the sham group had a mean airspace of 37.8 mm³ (95% C.I. 34.7–40.8 mm³) and 38.8 mm³ after sham treatment (95% C.I. 35.6–42.0 mm³) with no significant difference (p = 0.1609). (B) Saline treatment increased nasal airspace from 37.0 mm³ (95% C.I. 34.6–39.3 mm³) to 41.1 mm³ (95% C.I. 38.6–43.7 mm³; p < 0.0001). (C) Treatment with TCEP increased nasal airspace from 36.4 mm³ (95% C.I. 33.9–38.9 mm³) to 41.4 mm³ (95% C.I. 38.7–44.0 mm³; p < 0.0001). (D) TCEP treatment showed a greater increase in nasal airspace than saline or sham.