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. 2023 Jul 9;13(12):4004–4015. doi: 10.7150/thno.84865

Figure 3.

Figure 3

Synthesis of chemically-cleavable linker-chelators comprising a TCO functionalized on the releasing end (allylic position) with the [89Zr]Zr-DFO chelator. Reagents and conditions: (i) sarcosine, water, 10 min, RT (quantitative); (ii) PyBOP, DIPEA, deferoxamine mesylate salt, DMSO, 3h, RT (83%); (iii) deferoxamine mesylate salt, DMSO, 4 h, RT (84%); (iv) mal-amido-PEG9-amine, DMF, DIPEA, RT; (v) PyBOP, DIPEA, DMF, amino-PEG4-acid, 2 h, RT (14%); (vi) PyPOB, DIPEA, deferoxamine mesylate salt, DMSO, 4 h, RT (86%); (vii) mal-amido-PEG9-amine, DMF, DIPEA, 2 h, RT (11%).