Figure 7.

Evaluation of [⁸⁹Zr]Zr-Tmab-8 and trigger 10 in mice bearing BT-474 xenografts at two different time points. (A) Biodistribution (4 h post-trigger administration) of mice bearing BT-474 xenografts receiving [⁸⁹Zr]Zr-Tmab-8 alone or followed by trigger 10 at 6 h or 24 h post-mAb (B) Tumor-organ ratios from the mice in panel A The data represent the mean % ± SD (n = 5). Statistical analysis was performed using the unpaired Student's t-test, *p < 0.05, **p < 0.01, ***p < 0.001 and n.s.= not significant (A: tumor, 6 h: p = 0.1793; 24 h: p = 0.9042; B: tumor-muscle, 6 h: p = 0.1682; tumor-bone, 6 h: p = 0.2119; 24 h: p = 0.1219; tumor-fat, 6 h: p = 0.0719).