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. 2023 Jul 9;13(12):4004–4015. doi: 10.7150/thno.84865

Table 1.

Triggered release of radioactive fragment from [89Zr]Zr-TCO-Tmab conjugates in PBS. 89Zr-conjugates were mixed in PBS with an excess of trigger (300 eq) and incubated at 37 ºC for 24 h. Samples were analyzed using SEC. The data represent the mean % ± SD (n = 3).

89Zr-labeled Tmab Release induced by triggers (mean% ± SD)
9 10
[89Zr]Zr-Tmab-2 80.4 ± 0.6 69.3 ± 1.7
[89Zr]Zr-Tmab-4 88.5 ± 0.3 75.1 ± 0.8
[89Zr]Zr-Tmab-6 86.9 ± 0.1 68.2 ± 4.2
[89Zr]Zr-Tmab-7 63.2 ± 2.3 59.4 ± 9.8
[89Zr]Zr-Tmab-8 89.5 ± 0.5 78.1 ± 0.6