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. 2023 Jul 9;13(12):3966–3987. doi: 10.7150/thno.84133

Figure 7.

Figure 7

Illustration of the multilayered extrinsic and intrinsic mechanisms of regulating eNSPCs behavior post SCI. Delivering extrinsic niche signals (e.g. PTX, Curcumin, Epo, Substance P, CNTF, etc.) activates intracellular signaling pathways that induce changes in neurogenic gene expression. In addition, manipulating intrinsic transcriptional programs (e.g. transcription factors, epigenetic information, non-coding RNA, etc.) can direct neurogenic gene expression in eNSPCs. These strategies trigger eNSPC neurogenesis which leads to neural connection reconstruction and glial scar reduction. Arrows with dotted lines mean some steps of the signal pathway are omitted. Created with BioRender.com.