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. 2023 Jul 14;13(12):4042–4058. doi: 10.7150/thno.84388

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KLF7 expression is positively correlated with the expression levels of cytoplasmic HMGB1 and nucleus p-p65 in human HCC tissues. (A) Representative IHC staining of HMGB1, p-p65(Ser536) and KLF7 expression in HCC tissues and para-cancer nontumor specimens. (B) Correlation analysis of KLF7 expression and cytoplasmic HMGB1 or nucleus p-p65 (Ser536) expression in two independent HCC cohorts. (C-D) Overall survival and recurrence rates of HCC patients with positive or negative cytoplasmic HMGB1 (C) or p-p65 (D) in two independent cohorts. (E-F) The correlation of KLF7/cytoplasmic HMGB1 (E) or KLF7/p-p65 (F) co-expression and overall survival and recurrence rates in our HCC cohorts. (G) Representative IHC staining of HMGB1 and KLF7 expression in para-cancerous nontumor samples, HCC specimens, and metastatic HCC tissues. IHC scores of and HMGB1 were presented. *P < 0.05.