Skip to main content
. 2023 Jul 24;13(12):4197–4216. doi: 10.7150/thno.84059

Figure 4.

Figure 4

EVs derived from hypoxic microglia augment AQP4 polarity and attenuate astrogliosis in different regions of the periinfarct cortex and striatum. (A) Schematic diagram of the cortex and striatum at post-MCAO day 7 of interest along with representative immunofluorescence maps. (B-G) Statistical plots of the polarity of AQP4 and GFAP mean fluorescence intensity in the periinfarct region 1 (R1), R2, R3, R4, R5, and striatum (n = 6). The EV-treated mice exhibited a higher polarity of AQP4 in all periinfarct regions and striatum than those of the MCAO control mice. Likewise, the EV-treated mice were associated with a lower GFAP mean fluorescence intensity in the peri-infarct R2, R3, R4, and striatum. *p < 0.05; **p < 0.01; ****p < 0.0001; NS, not statistically significant; MCAO, middle cerebral artery occlusion; EVs, extracellular vesicles; AQP4, aquaporin 4.