Figure 1.

Activities of skeletal muscle as an endocrine organ

The activities of myokines in numerous organs and tissues, and the resulting effects are shown. Myokines are secreted by skeletal muscle. Autocrine myokines that promote muscular hypertrophy and regeneration are shown in the center of skeletal muscle. In particular, we referred to Reference, which shows the action of myokine in various fields.^74,75 FSTL-1: follistatin-like 1; VEGF: vascular endothelial growth factor; UCP-1: uncoupling protein 1; BAT: brown adipose tissue; WAT: white adipose tissue.