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Effects of lipopolysaccharide (LPS) and recombinant human soluble thrombomodulin (rTM) on serum H3 (a) and citrullinated H3 (citH3) levels (b). Mice were intraperitoneally (i.p.) injected with 10 mg/kg LPS (non-rTM group; ■, n=9), followed by 6 mg/kg rTM after 1 h (rTM group; ▲, n=9). Control group mice (●, n=9) were i.p. injected with saline instead of LPS or rTM. Blood was collected 8 h after LPS injection. Data are expressed as the median. * p<0.05.
