Table 4.
NRTI resistance and/or compensatory mutations in the RT domain and ADAPVEMs in HBV isolates of PLWH in the Colombian cohort.
| Patient ID | HIV viral load (copies/mL) | CD4+ counts (cells/mL) | HAART regimen | NRTI resistant mutation patterns in the RT domain of pol gene in HBV | Mutations in the envelope (S) gene of HBV | ||||
|---|---|---|---|---|---|---|---|---|---|
| Lamivudine | Adefovir | Entecavir | Tenofovir | Telbivudine | ADAPVEMs | ||||
| 0205–114 | 448 | 1,419 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sG47R, sM75V, sM103T, sC139F, sI195M |
| 0423–289 | 144 | 114,733 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sL97P, sW182*, sI195M |
| 0107–024 | 659 | 40 | LAM + ABC + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sI25V, sG102D, sI195M |
| 0324–246 | 117 | 165 | LAM + 4dT + NVP | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sI195M |
| 04–29-296 | 201 | 40 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sF85L, sL95S, sC139Y, sI195M |
| 0208–121 | 297 | 37,762 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | Resistant (rt204V, rt80I) | sT27A, sG47R, sC69S, sG71A, sR78W, sC90R, sA128T, sS167P, sI195M |
| 0318–227 | 590 | 16,312 | LAM + ABC + LPV + RTV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sL97P, sP120A, sI150V, sV184A, sI195M |
| 0319–230 | 220 | 40 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sI82V, sG130E, sI195M |
| 0326–249 | 335 | 40 | LAM + ABC + LPV + RTV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sC90R, sS167P, sI195M |
| 04–07-263 | 294 | 40 | LAM + ZDV + NVP | (rt180K, rt204V, rt80I) | -- | Partially resistant (rt204V, rt184N, rt180K) | -- | (rt204V, rt80I) | sW74R, sL88Q, sL97P, sL104F, sG112R, sT114K, sS132T, sW165*, sA168P, sW172R, sL176I, sI195M |
| 05–21-327 | 72 | 73,327 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Resistant (rt184S, rt204V, rt180M) | -- | (rt204V, rt80I) | sC65G, sG71E, sW74*, sF83L, sL87R, sI92T, sY100N, sC124G, sM133I, sC137G, sF170L, sL176V, sV177G, sI195M, sL216V, sF219L |
| 0105–005 | 745 | 40 | LAM + ZDV + LPV + RTV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sL97P, sS174N, sI195M |
| 0112–044 | 217 | 60,334 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | Unknown mutation (rt236Y) | Partially resistant (rt204V, rt250L, rt180M) | Unknown mutation (rt236Y) | (rt204V, rt80I) | sL192I, sI195M, sI208N, sL216V, sV224I, sI226T, s*227Y |
| 03–24-238 | 759 | 40 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sH60R, sM75K, sI195M, sL209P, sL216V |
| 0414–270 | 351 | 30,331 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sL97P, sI195M |
| 0422–283 | 29 | 78 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sP46S, sI195M |
| 05–26-341 | 178 | 45,108 | LAM + 4dT + LPV + RTV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sI195M, sF219L |
| 0629–359 | 687 | 40 | LAM + ZDV + NFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sM75K, sI86LMV, sF93L, sL94V, sD99G, sL104M, sP105L, sV106G, sC107*, sT114K, sT116S, sT118N, sP120A, sA128S, sC137*, sC149G, sP151R, sA157G, sI195M, sF219L |
| 0211–141 | 446 | 209 | LAM + ZDV + NVP | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sI195M |
| 0211–143 | 403 | 40 | LAM + ZDV + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sL45P, sP46H, sG47C, sC48W, sS58F, sI195M |
| 0212–154 | 34 | 29,058 | LAM + ABC + EFV | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sG159R, sC183W, sI195M, sY200F, sL205M, sL209P |
| 06–01-347 | 153 | 42,414 | LAM + ZDV + ABC | (rt180M, rt204V, rt80I) | -- | Partially resistant (rt204V, rt180M) | -- | (rt204V, rt80I) | sM75K, sI92F, sL97P, sT114K, sS117G, sP120A, sA128S, I195M, sF219L |
| 0119–077 | 342 | 319 | LAM + ddl + EFV | (rt180M, rt204V, rt80I) | -- | (rt250V, rt204V, rt180M) | -- | (rt204V, rt80I) | sK24E, sI195M |
| Control HBsAg-02 | Treatment naïve | -- | -- | -- | -- | -- | sC69* | ||
| Control HBsAg-07 | Treatment naïve | -- | -- | -- | -- | -- | - | ||
ABC, Abacavir; ddl, Didanosine; EFV, Efavirenz; LAM, Lamivudine; LPV, Lopinavir; NVP, Nevirapine; NFV, Nelfinavir; RTV, Ritonavir; ZDV, Zidovudine; 4dT, Stavudine.