Table 4.
Exposure to DINP and DPeP from gestational days 14 to 18 significantly reduces testis testosterone production (TPROD) and Insl3mRNA, measured on gestational day 18. These data were used to produce statistical models that compared the effects of the two phthalates on TPROD and Insl3mRNA with the rate of postnatal alterations in male rat offspring.
| Dose Response Data | % Control | ||
|---|---|---|---|
| DOSE | TPROD | Insl3 | |
| DINP | 500 | 70.5 | 73 |
| 750 | 63.1 | 79 | |
| 1000 | 43.1 | 56 | |
| 1500 | 31.6 | 51 | |
| DOSE | TPROD | Insl3 | |
| DPeP | 11 | 91.4 | 86 |
| 33 | 53.1 | 65 | |
| 100 | 24.3 | 47 | |
| 300 | 10.9 | 18 | |
| 750 | 12.5 | 21 | |