TABLE 3.
Key preclinical studies on combinatorial therapies for SCI.
| Author | Year | Modality | Result |
|---|---|---|---|
| Wang et al.49 | 2020 | Matrigel as scaffold material | Improved functional repair and behavioural recovery |
| Mothe et al.50 | 2013 | Hyaluronan-based hydrogel | Significant reduction in cavitation and sparing of perilesional host oligodendrocytes and neurons |
| Raynald et al.51 | 2019 | Polypyrrole/polylactic acid (PPy/PLA) nanofibrous scaffold | Promote the functional recovery of the spinal cord |
| Park et al.52 | 2012 | Matrigel | Improved functional recovery |
| Jiao et al.53 | 2017 | Silk fibroin/alginates/glial cell line-derived neurotrophic factor (SF/AGs/GDNF) scaffold | Better therapeutic and repair effects |
| Wang et al.54 | 2017 | Poly lactic-co-glycolic acid (PLGA) | Enhanced locomotor recovery, axon myelination and better protected neurons post SCI |
| Wang et al.55 | 2021 | Nerve growth factor | Enhanced the motor function of hindlimbs |
| Keikhaei et al.56 | 2023 | High-intensity interval training | Improved locomotor function |
| Shibata et al.57 | 2023 | Rehabilitative Training | Significant improvement in motor functions |
| Chen et al.58 | 2008 | Electro-acupuncture | Improved functional recovery |
| Ding et al.59 | 2009 | Electro-acupuncture | Significant functional recovery |
SCI, spinal cord injury.