Table 1.

Study Sample Characteristics: Baseline Values and Change over Follow-up

n=600	Mean(SD)
Age	62(8.9)
Female (%)	59%
African-American (%)	18%
BMI (kg/m2)	31(4.8)*
Depressive symptoms (CES-D)	10%**
Kellgren and Lawrence Grade
0	0
1	12.5%
2	51.0%
3	36.5%
WOMAC pain score Baseline (range:0–20)	2.4(3.1)
Change, Baseline to 24 months	0.62(3.4)
Change, Baseline to 36 months	0.93(3.7)**
Cartilage Thickness (mm), medial tib-fem compartment
Baseline (range: 1 to 8.6)	3.3(0.61)
Change, Baseline to 24 months (range: −2 to 2)	−0.10(0.21)*
Cartilage Thickness Score (MOAKS)
Baseline Score (range 0–42)	2.8(2.8)
Change, Baseline to 24 months range ± 42)	0.79 (1.56)
Synovitis Score (MOAKS)
Baseline (range 0–6)	1.53(1.19)
Change, Baseline to 24 months (range ± 6)	0.23(0.88)
BML size summary Score (MOAKS)
Baseline (range 0–45)	3.78 (2.79)
Change, Baseline to 24 months range ± 45)	−0.45(2.34)*

Values are Mean(SD) unless otherwise specified

^*N=599;

^**N=596