Table 2.

Association of cartilage thickness loss over 24 months with change in WOMAC knee pain over 24 or 36 months

	Outcome over 24 months Mean change in WOMAC Knee pain over 24 months* (95% CI)	Outcome over 36 months Mean change in WOMAC Knee pain over 36 months* (95% CI)
Exposure: 0.1 mm Cartilage Thickness Loss over 24 months	0.32(0.21,0.44)** p<.0001	0.19(0.07,0.32)** p=0.0025
BML at baseline (size summary score across 15 regions)	0.10(0.00,0.19) p=0.04	0.18(0.08,0.28) p=0.0005
Synovitis at baseline (summary score)	0.03(−0.18,0.24) p=0.80	−0.05(−0.28,0.18) p=0.66
Exposure: 0.05 mm Cartilage Thickness Loss over 24 months	0.16(0.10,0.22)** p<.0001	0.10(0.03,0.16)** p=0.0025
BML at baseline (size summary score across 15 regions)	0.10(0.00,0.19) p=0.04	0.18(0.08,0.28) p=0.0005
Synovitis at baseline (summary score)	0.03(−0.18,0.24) p=0.80	−0.05(−0.28,0.18) p=0.66

^*Model for each exposure and outcome: exposure + standard set of covariates (baseline age, sex, BMI, race, depressive symptoms, and pain) + baseline BML score + baseline synovitis score.

^**Values are unstandardized regression coefficients representing mean change in WOMAC knee pain over 24 or 36 months.

Positive(+) beta coefficient indicates an increase in WOMAC pain.