Wilkinson 2007.

Methods	Study design: RCT Country: UK Total: 288 randomised (aromatherapy with massage group n = 144, no‐massage group n = 144)
Participants	Population: people with cancer, referred to complementary therapy services with clinical anxiety or depression, or both Setting: recruited from 4 cancer centres and 1 hospice in England between September 1998 and May 2002 Mean age: 52.1 years
Interventions	Intervention: 4‐week course of weekly, 1‐hour sessions of aromatherapy massage Comparison: psychological support services as part of cancer care (usual supportive care) Country of training: not reported Years in practice: not reported
Outcomes	Outcome measures at randomisation, 6 weeks, and 10 weeks post‐randomisation Primary outcome Clinical anxiety or depression, or both (%) Secondary outcomes State Anxiety Inventory (SAI) Center for Epidemiological Studies Depression (CES‐D) European Organization of Research and Treatment of Cancer QoL questionnaire (EORTC QLQ‐C30)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomly assigned using random number sequence, and balanced in randomly sized blocks"
Allocation concealment (selection bias)	Low risk	Used numbered sealed opaque envelopes
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Assessed 6 same outcomes (SAI, CES‐D, EORTC‐pain, fatigue, nausea/vomiting, global QoL) at 6 weeks and 10 weeks post‐randomisation in both groups
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	67/288 lost to follow‐up Quote: "the data available at 6 and 10 weeks post randomisation were not representative of the complete sample of randomly assigned patients"
Selective reporting (reporting bias)	Unclear risk	Quote: "along with missing questionnaires, the continuous secondary outcome measures were considered missing if fewer than half of the items of a factor were completed"
Size	Low risk	n = 288
Other bias	Low risk	No other significant bias found

BMT: bone marrow transplantation; DBP: diastolic blood pressure; ms: millisecond; n: number of participants; QoL: quality of life;

RCT: randomised controlled trial; SBP: systolic blood pressure.