Table 1.
Characteristics of mechanically ventilated COVID-19 patients
| Patients who received noninvasive support after
extubation (n = 137) |
Patients who did not receive noninvasive support
after extubation (n = 247) |
p value | |
|---|---|---|---|
| Age (years) | 53.8 ± 13.1 | 53.9 ± 14.9 | 0.988 |
| Sex, male | 79 (57.7) | 133 (53.8) | 0.471 |
| SAPS 3 | 64.3 ± 13.2 | 61.2 ± 15.6 | 0.091 |
| PEEP in the first day (cmH2O) | 12.4 ± 3.4 | 11.2 ± 3.0 | < 0.001 |
| Plateau pressure in the first day (cmH2O) | 27.0 (24.0 - 30.0) | 26.0 (24.0 - 29.0) | 0.062 |
| PaO2/FiO2 preintubation | 84.0 (69.0 - 118.0) | 115.5 (82.0 - 209.0) | < 0.001 |
| NIV preintubation | 58 (42.3) | 60 (24.3) | < 0.001 |
| Fluid balance - last 24 hours (mL) | -4.0 (-544.0 - 900.0) | 0.0 (-666.3 - 499.3) | 0.412 |
| Duration of weaning (days) | 0.0 (0.0 - 0.0) | 0.0 (0.0 - 1.0) | 0.261 |
| Duration of MV (days) | 12.6 ± 7.0 | 10.0 ± 6.4 | < 0.001 |
| Reintubation at 48 hours | 34 (24.8) | 41 (16.6) | 0.052 |
| Reintubation at 96 hours | 44 (32.1) | 48 (19.4) | 0.005 |
| Reintubation in ICU | 56 (40.9) | 51 (20.6) | < 0.001 |
| ICU mortality | 23 (16.8) | 28 (11.3) | 0.132 |
| Hospital mortality | 30 (21.9) | 35 (14.2) | 0.053 |
SAPS 3 - Simplified Acute Physiology Score 3; PEEP - positive end-expiratory pressure; PaO2 - partial pressure of oxygen; FiO2 - fraction of inspired oxygen; NIV - noninvasive ventilation; MV - mechanical ventilation; ICU - intensive care unit. The results are expressed as the mean ± standard deviation, n (%) or median (interquartile range).