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Top, murine tissue-based indirect IFA. Patient CSF produced a synaptic pattern of IgG staining of the cerebellum (A) and hippocampus and thalamus (B). (C) NRXN3-transfected CBA. Neurexin3α-specific antibody, patient CSF, and patient serum (but not serum from a healthy donor [negative control]) were reactive. Nontransfected cells were nonreactive (not shown). IFA = immunofluorescence assay.
