Skip to main content
. 2023 Aug 7;10(5):e200145. doi: 10.1212/NXI.0000000000200145

Figure 3. SEZ6L2 Antibody by Tissue IFA.

Figure 3

Murine tissue-based indirect IFA from serum of patient 4 demonstrates neuronal cytoplasmic staining on a synaptic background, most prominent in the cerebellar granular layer and Purkinje cells (A) but also in the striatum (B), hippocampus (C), cerebral cortex (D) with adjacent myenteric nerves in the composite (arrow). HuProt array disclosed SEZ6L2 as high-ranking hits in serum (both patients) and CSF (available in patient 3), and SEZ6L2-transfected CBAs were positive in all samples (not shown). IFA = immunofluorescence assay.