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(A) Brain/plasma concentration–time data after 2.29 mg/kg dose. (B) Brain/plasma concentration–time data after 7.63 mg/kg dose.
| A | IP dose: 2.29 mg/kg | B | IP dose: 7.63 mg/kg | ||||
|---|---|---|---|---|---|---|---|
| Time (hr) | Brain concentration (ng/g) | Plasma (ng/mL) | Ratio (brain/plasma) | Time (hr) | Brain conc entration (ng/g) | Plasma (ng/mL) | Ratio (brain/plasma) |
| 1 | 15.6 | 340 | 0.0459 | 1 | 158 | 750 | 0.210* |
One animal artificially drove up blood/plasma ratio. N = 3 per dose.
