TABLE 1.
Writers, erasers, and readers for m6A.
| Name | Function | |
|---|---|---|
| Writer | METTL3 | Catalytic production of m6A modification |
| METTL14 | 1. Enhance methyl transferase activity in addition to stabilizing METTL3 | |
| 2. Recognize RNA substrates and methyl localization | ||
| WTAP | 1. Regulate METTL3/14 accumulation toward mRNAs | |
| 2. Methylation of specific mRNAs | ||
| Eraser | FTO | Demethylation |
| ALKBH5 | 1. Demethylation | |
| 2. Regulates mRNA export and stability | ||
| Reader | ||
| nucleus | YTHDF2 | Facilitates degradation |
| YTHDC1 | Alternative splicing, alternative polyadenylation, and nuclear export | |
| (HNRNP) A2B1/C/G | Pre-mRNA processing, mRNA metabolism, and nuclear export | |
| cytoplasm | YTHDF1/3, eIF | Facilitate translation |
| YTHDC2 | mRNA stability and translation | |
| (IGF2BP) 1/2/3 | mRNA stability and translation |