TABLE 2.
m6A in TNF-α-medicated diseases.
| Disease/cells | m6A | Up/Downstream | Functional outcome/correlation |
|---|---|---|---|
| Regulator (s) | Target (s) | ||
| MSCs | FTO↓ | Nanog↓ | Reduce stability |
| Atherosclerosis | METTL14↓ | FOXO1↑ | Promote transcription |
| Ankylosing spondylitis | METTL14↓ | ELMO1↑ | Reduce denaturation rate |
| Enhance directional migration | |||
| Intervertebral disc degeneration | METTL14↑ | MiR-34a-5p↑ | Cell cycle arrest and senescence |
| Lumbar disc herniation | WTAP↓ | NORAD↓ | Facilitates degradation |
| Diabetic nephropathy | METTL14↑ | α-klotho↓ | Decrease mRNA stability |
| Osteoarthritis | METTL3↓ | MMP1↑, MMP3↑ | Matrix degradation |
| MMP13↓, TIMP-1↓, TIMP-2↓ | |||
| Atherosclerosis | ALKBH5↓ | Bcl-2↓ | Apoptosis |
| Nephritis | METTL3↑ | TAB3↑ | Enhance stability |
| Temporomandibular joint osteoarthritis | METTL3↓ | m6A/Ythdf1/Bcl2 axis↓ | Enhance stability (Ythdf1) |
| YTHDF1↓ | |||
| Fungal keratitis | METTL3↓ | PI3K/AKT pathway↑ | Unknown |
| Myocardial inflammation | FTO↓ | Unknown | Unknown |
| Sepsis | YTHDF1↓ | YTHDF1/WWP1/NLRP3/caspase-1 axis↑ | Promote transcription |
| RAW 264.7 cells | YTHDF2↑ | MAP2K4, MAP4K4↑ | Stabilization |
| Osteoclastogenesis | YTHDF2↑ | NF-κB and MAPK pathway↑ | Reduce stabilization |
↑: upregulate ↓: downregulate.