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. 2023 Jun 22;7(8):1221–1231. doi: 10.1038/s41559-023-02095-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a) KEGG graph based on Homos sapiens gene IDs. A rectangle can contain multiple genes from the same homologous group, therefore we have only shown the representative gene name that KEGG uses, in the chart and table (b) as well. Colouring of the rectangles is based on the average copy number ratio between non-fungi and Fungi (Ratio N/F), warmer colour represents more members of a given HG in non-fungi than in Fungi. Green asterisk (*) indicates the absence of a component in the Saccharomyces pathway based on the KEGG pathway (sce04070), while blue stroke represents the absence of a component from Dikarya based on our clustering. b) The table shows the average copy numbers of the HGs in which the components of the pathway were clustered. The ratio (N/F) explained above was used to colour the rectangles in diagram (a).