Table 1.
Baseline Characteristics of All Patients with Systemic AL Amyloidosis (N = 351)
| Age, y | 65.46 ± 10.27 |
| Male | 209 (59.5) |
| Serum NT-proBNP, pg/L | 2,169 (645-5,541) |
| Serum troponin, ng/L | 48 (23-95) |
| Serum bilirubin, μmol/L | 6 (4-10) |
| Serum aspartate aminotransferase, IU/L | 25 (20-33) |
| Serum alanine aminotransferase, IU/L | 26 (19-35) |
| Serum alkaline phosphatase, IU/L | 92 (71-129) |
| SAP scintigraphy | |
| Liver uptake | 93 (26.5) |
| Spleen uptake | 195 (55.6) |
| Total amyloid load | |
| None | 151 (43.0) |
| Small | 53 (15.1) |
| Moderate | 79 (22.5) |
| Large | 68 (19.4) |
| Cardiac magnetic resonance | |
| LV mass, g | 150.05 ± 71.82 |
| LV mass indexed, g/m2 | 80.43 ± 36.06 |
| LV volume in diastole, mL | 130.15 ± 27.52 |
| LV volume in diastole indexed, mL/m2 | 71.02 ± 29.65 |
| LV volume in systole, mL | 45.31 ± 17.19 |
| LV volume in systole indexed, mL/m2 | 24.29 ± 9.18 |
| Stroke volume, mL | 84.80 ± 17.81 |
| Stroke volume indexed, mL/m2 | 45.18 ± 8.17 |
| Ejection fraction, % | 65.62 ± 8.71 |
| Myocardial native T1, ms | 1,139 (1,082-1,184) |
| Myocardial T2, ms | 50.87 ± 6.57 |
| Myocardial extracellular volume | 0.44 ± 0.10 |
| Liver and spleen extracellular volume | |
| Liver extracellular volume | 0.39 ± 0.12 |
| Spleen extracellular volume | 0.43 ± 0.17 |
Values are mean ± SD, n (%), or median (IQR).
AL = light chain; LV = left ventricular; NT-proBNP = N-terminal pro-brain natriuretic peptide; SAP = serum amyloid P component.