Table 2.
Multiorgan ECV Response to Treatment 6 Months After Initiating Chemotherapy, Compared With the Hematologic Response and Repeat SAP Scintigraphy at 6 Months
| All Patients Who Had Repeat CMR With ECV Mapping at 6 mo (N = 141, Liver ECV Measurable in 118 Patients and Spleen Measurable in 113 Patients) | ||||
|---|---|---|---|---|
| Hematologic Response | Complete Response (n = 57, 40.4%) | Very Good Partial Response (n = 28, 20.0%) | Partial Response (n = 36, 25.5%) | No Response (n = 20, 14.2%) |
| Liver ECV regression | 5 | 3 | 0 | 0 |
| Spleen ECV regression | 7 | 2 | 0 | 0 |
| Cardiac ECV regression | 4 | 0 | 0 | 0 |
| Stable liver ECV | 44 | 24 | 24 | 10 |
| Stable spleen ECV | 42 | 20 | 24 | 11 |
| Stable cardiac ECV | 43 | 20 | 18 | 11 |
| Liver ECV progression | 0 | 0 | 4 | 4 |
| Spleen ECV progression | 0 | 1 | 3 | 3 |
| Cardiac ECV progression | 10 | 8 | 18 | 9 |
| Patients With Repeat SAP Scintigraphy and CMR With ECV Mapping at 6 mo (N = 103, Liver ECV Measurable in 92 Patients and Spleen Measurable in 85 Patients) | ||||
|---|---|---|---|---|
| Liver Response | Liver Regression on SAP Scintigraphy (n = 3) | Stable Liver on SAP Scintigraphy (n = 84) | Liver Progression on SAP Scintigraphy (n = 5) | |
| Liver ECV regression | 2 | 4 | 0 | |
| Stable liver ECV | 1 | 79 | 2 | |
| Liver ECV progression | 0 | 1 | 3 | |
| Spleen Response | Spleen Regression on SAP Scintigraphy (n = 11) | Stable Spleen on SAP Scintigraphy (n = 68) | Spleen Progression on SAP Scintigraphy (n = 6) | |
|---|---|---|---|---|
| Spleen ECV regression | 6 | 4 | 0 | |
| Stable spleen ECV | 5 | 63 | 2 | |
| Spleen ECV progression | 0 | 1 | 4 | |
CMR = cardiac magnetic resonance; ECV = extracellular volume; other abbreviation as in Table 1.