TABLE 3.
Tumorigenicities of wild-type and mutant Ad9 viruses in Wistar-Furth ratsa
| Virus | No. of rats that developed tumors/ no. infected with virus
|
|
|---|---|---|
| Females | Males | |
| Ad9 | 3/3 | 0/2 |
| Ad9ΔE1A | 8/8 | 0/2 |
| Ad9ΔE1Bb | 3/3 | 0/3 |
| Ad26c | 0/3 | 0/3 |
a
Two- to three-day-old Wistar-Furth rats were injected subcutaneously with 7 × 107 PFU of virus. Animals were monitored by palpation for tumor development over an 8-month period.
b
Due to replication deficiencies of virus Ad9ΔE1B in 293 cells, the dose used to infect rats with this virus (8 × 106 PFU) was approximately ninefold lower than that used for the other viruses.
c
Ad26, a nononcogenic subgroup D human adenovirus closely related to Ad9 (31), served as a negative control in this experiment.