TABLE 4.
Histologies of wild-type and mutant Ad9-induced tumorsa
| Virus | Tumor sample | Histology |
|---|---|---|
| Wild-type Ad9 | 1 | Fibroadenoma |
| 2 | Fibroadenoma | |
| 3 | Fibroadenoma | |
| Ad9ΔE1A | 1 | Fibroadenoma, one area of increased cellularity |
| 2 | Focally cellular fibroadenoma | |
| 3 | Fibroadenoma | |
| 4 | Cellular fibroadenoma, focally increased mitoses, and focal phyllodes-like tumorb | |
| 5 | Fibroadenoma | |
| 6 | Fibroadenoma | |
| 7 | Fibroadenoma | |
| 8 | Fibroadenoma | |
| Ad9ΔE1B | 1 | Fibroadenoma |
| 2 | Fibroadenoma | |
| 3 | Fibroadenoma |
a
For histological examination, tumor samples were fixed in 10% formalin, and sections were stained with hematoxylin and eosin.
b
A section of this tumor contained an area resembling a phyllodes-like tumor, a type of mammary tumor occasionally observed in rats infected by wild-type Ad9 (29).