Table 2.
LOEC, EC50/IC50, and PCmax values derived from BNF exposure (adj. R2 and NRSME values are given as goodness-of-fit parameters of the nonlinear regression)
| Transfection setup (according to Fig. 4) | LOEC (adj. P-value) | EC50 (normalized; adj. R2; NRSME) | IC50 (normalized; adj. R2; NRSME) | EC50 (relative; non-normalized; adj. R2; NRSME) | IC50 (relative; non-normalized; adj. R2; NRSME) | PCmax (relative, non-normalized) | N (exp.) | |
|---|---|---|---|---|---|---|---|---|
| (a) | pGL4.43 + pGL4.70 | 10 nM (< 0.0001) | 2.95 nM (0.8; 0.39) | 24 nM (0.80; 0.32) | 2.45 nM (0.77; 0.02) | 27 nM (0.77; 0.02) | 15.8 nM (0.77; 0.02) | 4 |
| (b) | pGL4.43 + pRL-null | 10 nM (0.0044) | 490 pM (0.71; 0.71) | 106 nM (0.72; 0.55) | 309 pM (0.72; 0.03) | 109 nM (0.72; 0.02) | 15.7 nM (0.72; 0.02 | 3 |
| (c) | pGudLuc7.5 + pRL-null[zfEFapro] | 300 pM (0.003) | 63 pM (0.79; 0.31) | 73 nM (0.79; 0.31) | 87 pM (0.75; 0.03) | 72 nM (0.75; 0.03) | 19.5 nM (0.75; 0.03) | 5 |