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. 2023 Aug 7;10:36. doi: 10.1186/s40580-023-00385-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Adjuvant-encoded mRNA-LNP delivery system. a Cytokine levels in C57BL/6 mouse serum following treatment with STING-encoded mRNA-LNPs. b Flow cytometry analysis of IFN-γ, TNF-α, and IL-2 in the spleen after treatment with STING-encoded mRNA-LNPs. c Decreased lung metastasis observed in the E6/7 + NTFIX + DMXAA (STING-encoded mRNA-LNP) group after tumor challenge. d Survival rate in mice treated with STING-encoded mRNA-LNPs.

(Reproduced from a previous report [101] with permission from Elsevier)