FIG. 4.

Histopathology of pancreatic tissues from CB4-V-infected BALB/cByJ mice. Mice were infected intraperitoneally with 10⁴ PFU of CB4-V or mock infected with PBS. Pancreatic tissues were harvested at various times p.i., processed for histology, and stained with hematoxylin and eosin. (A) Mock-infected female; (B) mock-infected male. Panels A and B show normal pancreas. (C) CB4-V-infected female at day 7 p.i.; (D) CB4-V-infected male at day 7 p.i. Panels C and D show complete destruction of acini, with necrosis, and inflammatory cell infiltrate. Abbreviations: IL, islet of Langerhans; A, acini with zymogen granules; NA, necrotic acini; In, inflammatory cells. Magnification, ×306.