TABLE 3.
CB4-V infection results in a multistage disease
| Mouse strain | Gender | Treatment | % Mortalitya in stage:
|
||
|---|---|---|---|---|---|
| I (3–9 days) | II (10–21 days) | III (22–40 days) | |||
| BALB/cByJ | Male | None | 100 | ||
| CD4 ko | Male | None | 0 | 0 | 0 |
| IL-4 ko | Male | None | 0 | 47 | 0 |
| IFN-γ ko | Male | None | 100 | ||
| BALB/cByJ | Male | Anti-IFN-γ | 100 | ||
| BALB/cByJ | Male | Anti-CD8 | 50 | 0 | 0 |
| C57BL/6 | Male | None | 0 | 61 | 0 |
| CD8 ko | Male | None | 69 | 0 | 0 |
| BALB/cByJ | Female | None | 24 | 42 | 0 |
| CD4 ko | Female | None | 0 | 0 | 0 |
| IL-4 ko | Female | None | 0 | 0 | 21 |
| IFN-γ ko | Female | None | 4 | 17 | 0 |
| BALB/cByJ | Female | Anti-IFN-γ | 0 | 0 | 0 |
Percent mortality was determined from the number of mice that became moribund. Moribund mice were euthanized.