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. 1985 Aug;69(8):572–575. doi: 10.1136/bjo.69.8.572

Hyaluronate increases intraocular pressure when used in cataract extraction.

M S Passo, J T Ernest, T K Goldstick
PMCID: PMC1040681  PMID: 4016054

Abstract

A prospective randomised study of 26 eyes (24 patients) following uncomplicated intracapsular cataract surgery was carried out with three groups in which different agents were used to re-form the anterior chamber: air, seven eyes; sodium hyaluronate, seven eyes; and a combination of hyaluronate plus systemic acetazolamide, 12 eyes. The intraocular pressure (IOP) was measured by Goldmann applanation tonometry 16 hours before surgery and every eight hours after surgery for 72 hours. The IOP doubled in the two hyaluronate-treated groups for the first day following cataract surgery. By contrast, the IOP in the group receiving air initially decreased slightly. Throughout the study the effect of using acetazolamide was never statistically significant. After the first day and a half the differences in IOP among the three treatment groups disappeared, and the pressures returned to their preoperative values.

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Selected References

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  1. Anderson D. R. Experimental alpha chymotrypsin glaucoma studied by scanning electron microscopy. Am J Ophthalmol. 1971 Feb;71(2):470–476. doi: 10.1016/0002-9394(71)90120-6. [DOI] [PubMed] [Google Scholar]
  2. Balazs E. A., Freeman M. I., Klöti R., Meyer-Schwickerath G., Regnault F., Sweeney D. B. Hyaluronic acid and replacement of vitreous and aqueous humor. Mod Probl Ophthalmol. 1972;10:3–21. [PubMed] [Google Scholar]
  3. Berson F. G., Patterson M. M., Epstein D. L. Obstruction of aqueous outflow by sodium hyaluronate in enucleated human eyes. Am J Ophthalmol. 1983 May;95(5):668–672. doi: 10.1016/0002-9394(83)90388-4. [DOI] [PubMed] [Google Scholar]
  4. Binkhorst C. D. Inflammation and intraocular pressure after the use of Healon in intraocular lens surgery. J Am Intraocul Implant Soc. 1980 Oct;6(4):340–341. doi: 10.1016/s0146-2776(80)80031-0. [DOI] [PubMed] [Google Scholar]
  5. Brown S. V., Tye J. G., McPherson S. D., Jr Intraocular pressure after intracapsular cataract extraction. Ophthalmic Surg. 1984 May;15(5):389–393. [PubMed] [Google Scholar]
  6. Graue E. L., Polack F. M., Balazs E. A. The protective effect of Na-hyaluronate to corneal endothelium. Exp Eye Res. 1980 Jul;31(1):119–127. doi: 10.1016/0014-4835(80)90094-9. [DOI] [PubMed] [Google Scholar]
  7. Haimann M. H., Phelps C. D. Prophylactic timolol for the prevention of high intraocular pressure after cataract extraction. A randomized, prospective, double-blind trial. Ophthalmology. 1981 Mar;88(3):233–238. doi: 10.1016/s0161-6420(81)35053-2. [DOI] [PubMed] [Google Scholar]
  8. Hayasaka S., Sears M. L. Distribution of acid phosphatase, beta-glucuronidase, and lysosomal hyaluronidase in the anterior segment of the rabbit eye. Invest Ophthalmol Vis Sci. 1978 Oct;17(10):982–987. [PubMed] [Google Scholar]
  9. Holmberg A. S., Philipson B. T. Sodium hyaluronate in cataract surgery. I. Report on the use of Healon in two different types of intracapsular cataract surgery. Ophthalmology. 1984 Jan;91(1):45–52. [PubMed] [Google Scholar]
  10. Holmberg A. S., Philipson B. T. Sodium hyaluronate in cataract surgery. II. Report on the use of Healon in extracapsular cataract surgery using phacoemulsification. Ophthalmology. 1984 Jan;91(1):53–59. doi: 10.1016/s0161-6420(84)34340-8. [DOI] [PubMed] [Google Scholar]
  11. KIRSCH R. E. GLAUCOMA FOLLOWING CATARACT EXTRACTION ASSOCIATED WITH USE OF ALPHA-CHYMOTRYPSIN. Arch Ophthalmol. 1964 Nov;72:612–620. doi: 10.1001/archopht.1964.00970020612006. [DOI] [PubMed] [Google Scholar]
  12. Lang R. M., Hassard D. T. Effects on the corneal endothelium of anterior chamber reconstituents instilled during intracapsular cataract extraction. Can J Ophthalmol. 1981 Apr;16(2):70–72. [PubMed] [Google Scholar]
  13. Lazenby G. W., Broocker G. The use of sodium hyaluronate (Healon) in intracapsular cataract extraction with insertion of anterior chamber intraocular lenses. Ophthalmic Surg. 1981 Sep;12(9):646–649. [PubMed] [Google Scholar]
  14. Mac Rae S. M., Edelhauser H. F., Hyndiuk R. A., Burd E. M., Schultz R. O. The effects of sodium hyaluronate, chondroitin sulfate, and methylcellulose on the corneal endothelium and intraocular pressure. Am J Ophthalmol. 1983 Mar;95(3):332–341. doi: 10.1016/s0002-9394(14)78301-1. [DOI] [PubMed] [Google Scholar]
  15. Miller D., Stegmann R. Use of Na-hyaluronate in anterior segment eye surgery. J Am Intraocul Implant Soc. 1980 Jan;6(1):13–15. doi: 10.1016/s0146-2776(80)80097-8. [DOI] [PubMed] [Google Scholar]
  16. Packer A. J., Fraioli A. J., Epstein D. L. The effect of timolol and acetazolamide on transient intraocular pressure elevation following cataract extraction with alpha-chymotrypsin. Ophthalmology. 1981 Mar;88(3):239–243. doi: 10.1016/s0161-6420(81)35044-1. [DOI] [PubMed] [Google Scholar]
  17. Pape L. G., Balazs E. A. The use of sodium hyaluronate (Healon) in human anterior segment surgery. Ophthalmology. 1980 Jul;87(7):699–705. doi: 10.1016/s0161-6420(80)35185-3. [DOI] [PubMed] [Google Scholar]
  18. Percival S. P. Complications from use of sodium hyaluronate (Healonid) in anterior segment surgery. Br J Ophthalmol. 1982 Nov;66(11):714–716. doi: 10.1136/bjo.66.11.714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Polack F. M., Demong T., Santaella H. Sodium hyaluronate (Healon) in keratoplasty and IOL implantation. Ophthalmology. 1981 May;88(5):425–431. doi: 10.1016/s0161-6420(81)35017-9. [DOI] [PubMed] [Google Scholar]
  20. Rich W. J., Radtke N. D., Cohan B. E. Early ocular hypertension after cataract extraction. Br J Ophthalmol. 1974 Aug;58(8):725–731. doi: 10.1136/bjo.58.8.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sears D., Sears M. Blood-aqueous barrier and alpha-chymotrypsin glaucoma in rabbits. Am J Ophthalmol. 1974 Mar;77(3):378–383. doi: 10.1016/0002-9394(74)90744-2. [DOI] [PubMed] [Google Scholar]
  22. Smith J. A., Anderson D. R. Effect of the intraocular lens on intraocular pressure. Arch Ophthalmol. 1976 Aug;94(8):1291–1294. doi: 10.1001/archopht.1976.03910040163008. [DOI] [PubMed] [Google Scholar]

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