Table 2.

Model-estimated median daily colistin transit (as calculated from the median colistin concentration and clearance, Eq. (1) compared to the daily dose actually administered (back-calculated from water consumption on the day).

Targeted colistin dose (IU/kg BW/day)	Amount of colistin sulphate transit through the small intestine (mg/kg BW/day)	Amount of colistin base transit through the small intestine (IU/kg BW/day)	Mean daily dose of colistin administered (IU/kg BW/day)	Difference (%) between real and nominal dose
75,000	2.35	70,534	78,023	− 9.60
100,000	3.05	91,627	97,667	− 6.18
150,000	4.66	139,935	141,133	− 0.85