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Computation of 10th and 50th percentile of AUC24h/MIC (h) for 3 MIC levels, using the 1-compartment classical (physiologically naïve) PK model.
Simulation was carried out for 5 dosage regimens. Percentiles; 10 and 50% (shaded column). MIC values in CAMHB were 2.4 mg/L for 120h_B3_5 (green), 2 mg/L for ECOFF (yellow) and 0.125 mg/L for N100 (grey). Median colistin concentration in luminal intestinal content (gut) expressed in mg colistin/kg intestinal content (blue).
