Table 4.

Critical values of the PK/PD index fAUC_{(PK 0–24 h)}/MIC (h) to achieve 50% of the maximal possible in silico effect for the combined population, for the S1 (susceptible) sub-population independently, and for S2 (less-susceptible) sub-population independently.

Representative strain	fAUC(PK 0–24 h)/MIC (h)*			Average free concentration (expressed as multiples of MIC, unitless) to achieve 50% kill effect
	Total population (S1 + S2)	Sub-population S1 only	Sub-population S2 only	Total Heteroresistant population (S1 + S2)	Sub-population S1 only	Sub-population S2 only
mcr-negative E. coli N100 (MIC = 0.125 mg/L)	26.2	8.4	38.1	1.1	0.35	1.59
mcr-positive E. coli 120h_B3_5 (MIC = 2.4 mg/L)	27.6	18.7	37.9	1.2	0.78	1.58