Table 5.

Summary table comparing the probability of target attainment (PTA%) for the estimated 50% pharmacodynamic AUC_24h/MIC target values (PDT) for the total population, S1 sub-populations, and S2 sub-population for 2 representative bacteria (mcr-negative N100 and mcr-positive 120h_B3_5) having MIC of 0.125 and 2.4 mg/L respectively (see Table 4).

Results were obtained, by simulating the one-compartment model selected to describe the intestinal colistin disposition, with 4 dosage regimens (75,000, 100,000, 150,000 IU/kg/day 75,000 IU/kg/6 h pulse, in DW), in 500 individuals. For a bacterium with an MIC equal to ECOFF of 2 mg/L, both PD targets were explored (mcr-negative and positive) through extrapolation of the respective PD parameters. Green cells represent the attainment of the pharmacodynamic target in ≥ 90% of the individuals of the population.