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. 2023 Aug 7;14:4746. doi: 10.1038/s41467-023-40439-y

Fig. 7. Regulating gut microbiota by SCXN.

Fig. 7

CT-26 tumor-bearing mice were treated with different formulations for 20 d and fecal samples were collected for 16 S rDNA sequencing before (Day 0), in the middle of (Day 10), and at the end of (Day 20) the treatment. a Microbial α-diversity in terms of Shannon index at the ASV level. b Microbial β-diversity NMDS analysis based on Bray-Curtis distance at the ASV level at the end of the treatment. c Heatmap showing relative abundance of the gut microbiota at the family level (displayed as normalized Z-score). d Barplot showing relative abundance of the gut microbiota at the genus level. e Change of the relative abundance of Akkermansia, Roseburia, Fecalibaculum, and Bifidobacterium during 20-day treatment process. f LefSe analysis cladogram representing the significantly different taxas between different groups from phylum to genus levels at the end of the treatment (LDA > 2, p < 0.05). g Summary of fecal SCFA levels and butyric levels in feces from CT26 tumor-bearing mice after different treatments. Data represent the mean ± SD (n = 5 mice). Statistical significance was calculated using one-way ANOVA with Tukey’s multiple comparisons test. Source data are provided as a Source Data file.