TABLE 1.
Phenotypes of RBD mutants
| Name | Mutation | Relative binding (%)a | Receptor-triggered protease sensitivityb | Receptor-triggered membrane associationb | Relative infectivity (%)a |
|---|---|---|---|---|---|
| wtc | 100 | + | + | 100 | |
| M20 | R213A/K227A | 14 | + | Delayede | 7 |
| M21 | R213A/R223A/R234A | 11 | −d | − | 5 |
| M28 | R213S | 91 | + | − | 5 |
From reference 42.
+, present; −, absent.
wt, wild type.
Sensitivity to thermolysin was independent of sTva.
Membrane association was delayed.