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Neurovirulence analysis of YF/JE chimerasa
| Virus | Dose (log10 PFU) | % Mortality (no. dead/no. tested) |
|---|---|---|
| YF5.2iv | 4 | 100 (7/7) |
| YF/JE-S | 6 | 0 (0/8) |
| 5 | 0 (0/7) | |
| 4 | 0 (0/7) | |
| YF/JE-N | 4 | 100 (5/5) |
| 3 | 100 (5/5) | |
| 2 | 100 (5/5) | |
| 1 | 60 (3/5) | |
| 0 | 0 (0/5) |
ICR mice (4 weeks old) received YF5.2iv, YF/JE-S, or YF/JE-N at the indicated doses by intracerebral inoculation.
